first, i'm going to add the requester's context here, to help other readers:
"These ppl do not understand wealth building and have gotten in the way in the past. ie: Asking for advice without doing the work. Asking to start something with me when they have no skills. Will ask for money if they knew I had become rich."
if the question was "while having poor friends," my answer would be simple: cut them out of your life. they're a tumor.
but it has that dreaded word... family.
here's the deal:
i've cut out many people from my life. some family, some friends, some acquaintances, some bosses, some neighbors. you have one life, and nobody will give you a 2nd try.
so pick your poison. tell your uncle "sorry man, i can't help you, you need to pave your own way." or, slink back in your chair while the world keeps turning.